Strategizing the Development of Alzheimer’s Therapeutics

NEP, ACE and Homologues: The Pathophysiology of Membrane Metalloproteases

The zinc metalloprotease, neprilysin (NEP), plays a role in the metabolism of cardiovascular, inflammatory and neuropeptides, including mitogenic peptides such as bombesin. In the cardiovascular system, NEP has a primary role in the inactivation of natriuretic peptides but also contributes to local metabolism of angiotensin, endothelins and bradykinin. Hence NEP is seen as a potential therapeut...

Strategizing vs. economizing: Theorizing dynamic competitive behavior in disequilibrium

1. Introduction 2. Profits are earned in disequilibrium Perfectly competitive equilibrium Assumptions of PCE PCE vs. dynamic strategic positioning (DSP) Profits as residual: Categories of income Measures of entrepreneurial profit 3. The firm as vehicle of strategizing behavior The elemental attributes of the strategizing firm The firm in the dynamic resource economy Strategizing around activiti...

Strategizing Slum Improvement in India: A Method to Monitor and Refocus Slum Development Programs

Alzheimer’s Disease: Current and Future Treatments. A Review

Alzheimer’s disease (AD) is a currently incurable neurodegenerative disorder whose treatment poses a big challenge. Proposed causes of AD include the cholinergic, amyloid and tau hypotheses. Current therapeutic treatments have been aimed at dealing with the neurotransmitter imbalance. These include cholinesterase inhibitors and N-Methyl-D-aspartate (NMDA) antagonists. However, current therapeut...

Antioxidant Property of Jobelyn as the Possible Mechanism Underlying its Anti-amnesic Activity in Rodents

Introduction: Amnesia or loss of memory is the cardinal hallmark of Alzheimer’s disease (AD), a progressive neurodegenerative disorder associated with ageing process. Although, AD had been discovered over a century ago, drugs which could cure or halt the progression of the disease are yet to see the light of the day. However, there has been a growing interest in the use of phytomedicines with m...